Transcripts of the multidrug resistance genes in chloroquine-sensitive and chloroquine-resistant Plasmodium falciparum
Identifieur interne : 002D18 ( Main/Exploration ); précédent : 002D17; suivant : 002D19Transcripts of the multidrug resistance genes in chloroquine-sensitive and chloroquine-resistant Plasmodium falciparum
Auteurs : R. M. Ekong [Royaume-Uni] ; K. J. H. Robson ; D. A. Baker ; D. C. WarhurstSource :
- Parasitology [ 0031-1820 ] ; 1993-02.
Abstract
Homologues of the mammalian multidrug resistance gene have been identified in isolates and clones of Plasmodium falciparum and designated pfmdr1 and pfmdr2. Mutations in pfmdr1 have been associated with chloroquine resistance but confirmation could not be obtained in a genetic cross. We have examined the copy number and expression of pfmdr1 and pfmdr2 in chloroquine-sensitive and -resistant P. falciparum and have found no relationship between the copy number of either gene and chloroquine resistance. However, a marked correlation was seen between levels of mRNA transcribed for each gene and chloroquine resistance. Two transcripts of pfmdr1 were detected, and in the asexual blood cycle an 8 kb transcript appeared first, followed by the appearance of a 7 kb species.
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DOI: 10.1017/S0031182000074904
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M." last="Ekong">R. M. Ekong</name><affiliation></affiliation><affiliation wicri:level="4"><orgName type="university">University College de Londres</orgName><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Robson, K J H" sort="Robson, K J H" uniqKey="Robson K" first="K. J. H." last="Robson">K. J. H. Robson</name><affiliation><wicri:noCountry code="subField">9DU</wicri:noCountry></affiliation></author><author><name sortKey="Baker, D A" sort="Baker, D A" uniqKey="Baker D" first="D. A." last="Baker">D. A. Baker</name><affiliation><wicri:noCountry code="subField">7HT</wicri:noCountry></affiliation></author><author><name sortKey="Warhurst, D C" sort="Warhurst, D C" uniqKey="Warhurst D" first="D. C." last="Warhurst">D. C. Warhurst</name><affiliation><wicri:noCountry code="subField">7HT</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j">Parasitology</title><title level="j" type="abbrev">Parasitology</title><idno type="ISSN">0031-1820</idno><idno type="eISSN">1469-8161</idno><imprint><publisher>Cambridge University Press</publisher><pubPlace>Cambridge, UK</pubPlace><date type="published" when="1993-02">1993-02</date><biblScope unit="volume">106</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="107">107</biblScope><biblScope unit="page" to="115">115</biblScope></imprint><idno type="ISSN">0031-1820</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0031-1820</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Homologues of the mammalian multidrug resistance gene have been identified in isolates and clones of Plasmodium falciparum and designated pfmdr1 and pfmdr2. Mutations in pfmdr1 have been associated with chloroquine resistance but confirmation could not be obtained in a genetic cross. We have examined the copy number and expression of pfmdr1 and pfmdr2 in chloroquine-sensitive and -resistant P. falciparum and have found no relationship between the copy number of either gene and chloroquine resistance. However, a marked correlation was seen between levels of mRNA transcribed for each gene and chloroquine resistance. Two transcripts of pfmdr1 were detected, and in the asexual blood cycle an 8 kb transcript appeared first, followed by the appearance of a 7 kb species.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement><orgName><li>University College de Londres</li></orgName></list><tree><noCountry><name sortKey="Baker, D A" sort="Baker, D A" uniqKey="Baker D" first="D. A." last="Baker">D. A. Baker</name><name sortKey="Robson, K J H" sort="Robson, K J H" uniqKey="Robson K" first="K. J. H." last="Robson">K. J. H. Robson</name><name sortKey="Warhurst, D C" sort="Warhurst, D C" uniqKey="Warhurst D" first="D. C." last="Warhurst">D. C. Warhurst</name></noCountry><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Ekong, R M" sort="Ekong, R M" uniqKey="Ekong R" first="R. M." last="Ekong">R. M. Ekong</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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